Specific Polymorphic Variation in the Mitochondrial Genome and Increased In-Hospital Mortality After Severe Trauma

摘要

Humans have 2 genomes, the large nuclear genome and a smaller genome residing in the mitochondria. Genes encoded in the mitochondrial DNA are vital for energy production. In this study, a specific polymorphic variation in the mitochondrial genome (mtDNA) (4216T) is associated with in-hospital mortality after admission to a trauma intensive care unit.